Method for Manufacturing Optically Active Fluorolactic Acid Derivative

摘要

A production method of an optically active fluorolactic derivative according to the present invention includes asymmetrically reducing a fluoropyruvic acid derivative (or fluoropyruvic acid hydrate) with the use of an α-keto acid dehydrogenase or α-keto acid reductase. The optically active fluorolactic derivative can be obtained with high optical purity under mild reaction conditions by the asymmetric reduction reaction of the fluoropyruvic acid derivative with the specific enzyme.

主权项

1. A method for producing an optically active fluorolactic derivative of the formula 2, comprising: asymmetric reduction of a fluoropyruvic acid derivative of the formula 1 or a fluoropyruvic acid hydrate of the formula 5 with the use of an α-keto acid dehydrogenase or α-keto acid reductasewhere n represents an integer of 1 to 3; and R represents a hydrogen atom or a C1-C10 straight or branched alkyl groupwhere n and R have the same meanings as in the formula 1where n and R have the same meanings as in the formula 1; and * represents an asymmetric carbon.