Synthetic Surfaces For Culturing Stem Cell Derived Cardiomyocytes

摘要

Synthetic surfaces suitable for culturing stem cell derived cardiomyocytes contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many cases, are suitable for culturing stem cell derived cardiomyocytes in chemically defined media.

主权项

1. A cell culture article for culturing stem cell-derived cardiomyocytes in a chemically defined medium, comprising:
a substrate having a surface; a polymer material disposed on the surface, wherein the polymer material comprises
(i) a homopolymer formed from tetra(ethylene glycol) diacrylate, glycerol dimethacrylate, triethylene glycol dimethacrylate, 1,4-butanediol dimethacrylate, or poly(ethylene glycol) diacrylate, or(ii) a copolymer formed fromtetra(ethylene glycol) diacrylate and 1,4-butanediol dimethacrylate,glycerol dimethacrylate and tetra(ethylene glycol) diacrylate,glycerol dimethacrylate and tri(ethylene glycol) dimethacrylate,glycerol dimethacrylate and 1,4-butanediol dimethacrylate,glycerol dimethacrylate and poly(ethylene glycol) diacrylate,triethylene glycol dimethacrylate and 1,4-butanediol dimethacrylate,poly(ethylene glycol) diacrylate and tetra(ethylene glycol) diacrylate,di(ethylene glycol) dimethacrylate and tetraethylene glycol dimethacrylate,tetra(ethylene glycol) diacrylate and trimethylolpropane triacrylate,trimethylolpropane triacrylate and neopentyl glycol ethoxylate diacrylate,di(ethylene glycol) dimethacrylate and tetra(ethylene glycol) diacrylate,di(ethylene glycol) dimethacrylate and tri(ethylene glycol) dimethacrylate,di(ethylene glycol) dimethacrylate and neopentyl glycol dimethacrylate,tetra(ethylene glycol) dimethacrylate and tri(ethylene glycol) dimethacrylate,tetra(ethylene glycol) dimethacrylate and 1,4-butanediol dimethacrylate,tetra(ethylene glycol) dimethacrylate and 1,6-hexanediol ethoxylate diacrylate,1,6-hexanediol propoxylate diacrylate and poly(ethylene glycol) diacrylate,1,6-hexanediol propoxylate diacrylate and trimethylolpropane benzoate diacrylate,1,6-hexanediol propoxylate diacrylate and trimethylolpropane ethoxylate (1 EO/OH) methyl diacrylate,1,6-hexanediol propoxylate diacrylate and 1,6-hexanediol ethoxylate diacrylate,neopentyl glycol diacrylate and trimethylolpropane ethoxylate (1 EO/OH) methyl diacrylate, orneopentyl glycol diacrylate and 1,6-hexanediol ethoxylate diacrylate.