SYSTEM AND METHOD FOR NUCLEOTIDE SEQUENCING

摘要

The present invention provides a system and method of sequencing complex molecules including DNA, RNA, proteins, and glycans. The method includes the steps of modifying a field effect nanopore transistor device with chemical recognition molecules, translocating the complex molecule into the field effect nanopore transistor device, applying bias potential to the silicon gate of the field effect nanopore transistor device, and measuring the resulting change in drain current across the source drain contacts.