| 摘要 |
Described herein are methods and compositions useful for enhancing pigmentation, such as skin, eye and/or hair pigmentation comprising administering e.g., an NNT inhibitor or an agent that modifies redox status in a melanocyte. The methods and compositions provided herein are based on the discovery that modification of the reduction/oxidative status of a cell (e.g., a melanocyte) by inhibition of nicotinamide nucleotide transhydrogenase (NNT) enhances skin pigmentation. Thus, modulating the cutaneous pigmentation via modification of such a specific redox-system mechanism can be used to prevent melanoma formation and to treat pigmentation disorders. |
