FRET MOLECULAR PROBES WITH CLEAVABLE LINKERS FOR DETECTING BACTERIA AND/OR FUNGI IN VITRO AND IN VIVO
摘要
An optical probe is provided comprising a probe element connected to a quencher by a cleavable linker; the probe element comprising a binding moiety, and a fluorophore being substantially fluorescently quenched by the quencher when the probe element is connected to the quencher by the cleavable linker; wherein the probe element is separated from the quencher when the cleavable linker is cleaved. Methods of using the probe are also provided.
申请公布号
WO2016075481(A1)
申请公布日期
2016.05.19
申请号
WO2015GB53452
申请日期
2015.11.13
申请人
THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人
BRADLEY, MARK;LILIENKAMPF, ANNAMARIA HELENA;AVLONITIS, NIKOLAOS;ESCOBAR, MARC VENDRELL;MCDONALD, NEIL ALEXANDER;HASLETT, CHRISTOPHER;DHALIWAL, KANWALDEEP;WALSH, TIMOTHY SIMON