发明名称 PREDICTING GENETICALLY STABLE RECOMBINANT PROTEIN PRODUCTION IN EARLY CELL LINE DEVELOPMENT
摘要 The present invention relates in general to the field of recombinant protein expression. In particular, the present invention relates to a method for selecting a suitable candidate cell clone for recombinant protein expression and to a host cell for recombinant protein expression, the host cell exhibiting artificially modified gene expression of at least one gene selected from the group consisting of: Hist1h2bc, Egrl, BX842664.2/Hist 1h3c, Dhfr, Fgfr2, AC115880.11, Mmp10, Vsnll (optional), CU459186.17, El 30203 B14Rik, Cspg4, C1qtnf1, Foxp2, and Ptpre.
申请公布号 WO2016075216(A1) 申请公布日期 2016.05.19
申请号 WO2015EP76390 申请日期 2015.11.12
申请人 LEK PHARMACEUTICALS D.D. 发明人 JAMNIKAR, UROŠ;GRUDEN, KRISTINA
分类号 C12Q1/68;G01N33/50 主分类号 C12Q1/68
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