DIANHYDROGALACTITOL TOGETHER WITH RADIATION TO TREAT NON-SMALL-CELL CARCINOMA OF THE LUNG AND GLIOBLASTOMA MULTIFORME
摘要
The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of non-small-cell lung carcinoma (NSCLC) and for the treatment of glioblastoma multiforme (GBM). Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide; the drug acts independently of the MGMT repair mechanism.
申请公布号
WO2016077264(A1)
申请公布日期
2016.05.19
申请号
WO2015US59814
申请日期
2015.11.10
申请人
DEL MAR PHARMACEUTICALS;BACHA, JEFFREY, A.;BROWN, DENNIS, M.;STEINØ, ANNE;FOUSE, SHAUN