| 发明名称 |
THERAPEUTIC DELIVERY VESICLES |
| 摘要 |
The present invention pertains to inter alia therapeutic delivery vesicles, for instance exosomes or microvesicles, comprising polypeptide constructs, methods for producing said therapeutic delivery vesicles, pharmaceutical compositions and medical uses thereof. The therapeutic polypeptide constructs comprised in the extracellular delivery vesicles enable sequestering target molecules of interest, to treat e.g. neuro-inflammatory diseases and cancer. |
| 申请公布号 |
US2016137716(A1) |
申请公布日期 |
2016.05.19 |
| 申请号 |
US201414784015 |
申请日期 |
2014.04.10 |
| 申请人 |
El Andaloussi Samir |
发明人 |
EL ANDALOUSSI Samir;WIKLANDER Oscar;NORDIN Joel;SMITH Edvard;GRINNEMO Karl-Henrik;SIMONSON Oscar |
| 分类号 |
C07K14/705 |
主分类号 |
C07K14/705 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A therapeutic delivery vesicle comprising attached to its membrane a polypeptide construct, wherein the polypeptide construct comprises at least one carrier polypeptide fused to at least one therapeutic polypeptide decoy receptor present at least partially on the outside of the delivery vesicle and wherein the at least one therapeutic polypeptide decoy receptor is signalling-incompetent. |
| 地址 |
Huddinge SE |
