| 发明名称 |
FCRN-SPECIFIC HUMAN ANTIBODY AND COMPOSITION FOR TREATMENT OF AUTOIMMUNE DISEASES |
| 摘要 |
The present invention relates to a human antibody specific for FcRn that is a receptor with a high affinity for IgG, a production method thereof, a composition for treating autoimmune disease, which comprises the antibody, and a method of treating and diagnosing autoimmune disease using the same. The FcRn-specific antibody according to the present invention can bind to FcRn non-competitively with IgG or the like to reduce serum auto-antibody levels, and thus can be used for the treatment of autoimmune diseases. |
| 申请公布号 |
US2016137713(A1) |
申请公布日期 |
2016.05.19 |
| 申请号 |
US201414899554 |
申请日期 |
2014.06.20 |
| 申请人 |
Hanall Biopharma Co., Ltd. |
发明人 |
Kim Sung Wuk;Park Seung Kook;Jeong Jae Kap;Kim Min Sun;Kim Eun Sun;Heo Jeong Haing;Song Yeon Jung;Yong Hae-Young;Shin Dongok |
| 分类号 |
C07K14/705;G01N33/566;A61K49/00 |
主分类号 |
C07K14/705 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A heavy-chain variable region of FcRn-specific antibody, which comprises CDR1, CDR2 and CDR3 contained in any one amino acid sequence selected from the group consisting of even numbers between SEQ ID NOS: 2 to 144, or in an amino acid sequence set forth in SEQ ID NO: 289 or 291, or a heavy-chain variable region having a sequence homology thereto of at least 90%. |
| 地址 |
Daejeon KR |
