发明名称 |
HIV-1 ANTIBODIES AND USES THEREOF (ADCC AND BISPECIFIC ABS) |
摘要 |
The present invention relates, in general, to HIV-1 antibodies including antibodies which bind to the surface of HIV-1 virus infected cells and/or mediate antibody-dependent cellular cytoxicity (ADCC)-, and, in particular, to ADCC-mediating antibodies (and fragments thereof) suitable for use, for example, in reducing the risk of HIV-1 infection in a subject. The invention is directed to bispecific antibody molecules which comprise an arm targeting HIV-1 and a second arm targeting an effector cell. The invention further relates to compositions comprising such antibodies or antibody fragments, and their therapeutic use. |
申请公布号 |
WO2016054053(A3) |
申请公布日期 |
2016.05.19 |
申请号 |
WO2015US52963 |
申请日期 |
2015.09.29 |
申请人 |
DUKE UNIVERSITY |
发明人 |
WILLIAMS, WILTON;HAYNES, BARTON, F.;MOODY, M., ANTHONY;LIAO, HUA-XIN;FERRARI, GUIDO;EASTERHOFF, DAVID |
分类号 |
A61K39/42;A61P31/18;C07K16/10 |
主分类号 |
A61K39/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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