| 发明名称 |
TUBULYSIN ANALOGS AND METHODS OF MAKING AND USE |
| 摘要 |
Tubulysin analogs of the formula (I), where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety. |
| 申请公布号 |
WO2016077260(A1) |
申请公布日期 |
2016.05.19 |
| 申请号 |
WO2015US59807 |
申请日期 |
2015.11.10 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
PEREZ, HEIDI L.;WEI, DONNA D.;BORZILLERI, ROBERT M.;GANGWAR, SANJEEV;SCHROEDER, GRETCHEN M.;CHENG, HENG;SCHMIDT, ROBERT J. |
| 分类号 |
C07K5/062;A61P35/00;C07D277/24;C07K5/078 |
主分类号 |
C07K5/062 |
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