Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta TCR -binding polypeptide

摘要

The present disclosure is related to improved methods for use of a humanized binding polypeptide specific for the alpha beta T cell receptor (α&bgr;-TCR). In particular, this disclosure relates to improved methods of use of a humanized anti-α&bgr;-TCR antibody, which is derived from the murine monoclonal antibody BMA031, in immunosuppressive therapy. Novel methods using humanized monoclonal antibodies and/or humanized monoclonal antibody fragments (e.g., anti-α&bgr;TCR antibodies and/or fragments thereof) are also provided. Novel methods using repetitive administration of humanized monoclonal antibodies and/or humanized monoclonal antibody fragments (e.g., anti-α&bgr;TCR antibodies and/or fragments thereof) to reduce α&bgr; T cells in the subject relative to γδ T cells in the subject are provided.