| 发明名称 |
METHOD OF SUPPRESSING GENE TRANSCRIPTION THROUGH HISTONE LYSINE METHYLATION |
| 摘要 |
The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a viral SET domain histone lysine methyltransferase (vSET or vSET-like protein) methylates lysine 27 of a gene's histone protein 3 (H3-K27) thereby suppressing the transcription of the gene. |
| 申请公布号 |
US2016137989(A1) |
申请公布日期 |
2016.05.19 |
| 申请号 |
US201615003174 |
申请日期 |
2016.01.21 |
| 申请人 |
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI |
发明人 |
Zhou Ming-ming;Mujtaba Shiraz |
| 分类号 |
C12N9/10 |
主分类号 |
C12N9/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition for human administration comprising a purified fusion protein comprising a Chlorella virus SET domain of a viral histone lysine methyltransferase protein (vSET), or a vSET-like protein, fused to a protein that binds to a target gene, in a pharmaceutically acceptable carrier. |
| 地址 |
New York NY US |
