| 主权项 |
1. A compound having the formula (I): or a pharmaceutically acceptable salt, hydrate or solvate thereof, wherein, the subscript n is 1 or 0; A is —C(O)—, —NH—, —SO2—, —CH2—, or —CHR3—; B is a bond, —C(O)—, —NH—, —CH2—, or —CHR3—; T is a bond, —CH2—, —NH—, —O—, —OCH2—, —C(O)CH2—, or —CR3R4—; wherein when A is —NH— and B is —C(O)—, then T is other than —C(R3)(R4)—; D is N or C(R5); E is N or C(R6); V is a bond, —O—, or —C(R5a)2; G is an optionally substituted aryl, optionally substituted heteroaryl, or an optionally substituted 9- or 10-membered fused bicyclic heteroaryl; J1 is CH, N or C(R2), when R2 is attached to the ring vertex identified as J1; R1 and R2 are independently hydrogen, halogen, optionally substituted C1-C4 haloalkyl, optionally substituted C3-C6 cycloalkyl, optionally substituted 3- to 6-membered cycloheteroalkyl, optionally substituted phenyl, optionally substituted heteroaryl, optionally substituted C1-C4 alkyl, optionally substituted C1-C4 alkoxy, CN, SO2NH2, NHSO2CH3, NHSO2CF3, OCF3, SO2CH3, SO2CF3, or CONH2, and when R1 and R2 are on adjacent vertices of a phenyl ring they may be joined together to form a 5- or 6-membered cycloheteroalkyl ring having one or two ring vertices independently selected from O, N and S, wherein said cycloheteroalkyl ring is optionally substituted with from one to three members selected from fluoro and C1-C3 alkyl; R3 and R4 are independently hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 haloalkyl, fluorine, OH, CN, CO2H, C(O)NH2, N(R5a)2, optionally substituted —O—C1-C6 alkyl, —(CR5R5)m—OH, —(CR5R5)m—CO2H, —(CR5R5)m—C(O)NH2, —(CR5R5)m—C(O)NHR5a, —(CR5R5)mN(R5a)2, —NH(CR5R5)mCO2H or —NH(CR5R5)m—C(O)NH2; each R5 is independently H, F, OH, optionally substituted C1-C6 alkyl or optionally substituted —O—C1-C6 alkyl; each R5a is independently H, or optionally substituted C1-C6 alkyl; R6 is H, OH, F, optionally substituted C1-C6 alkyl, optionally substituted —O—C1-C6 alkyl, or —N(R5a)2; and each m is independently 1, 2, or 3. |
