发明名称 |
SOLID DISPERSIONS OF AMORPHOUS PAROXETINE MESYLATE |
摘要 |
The invention relates to solid dispersions containing paroxetine mesylate. One solid dispersion contains amorphous paroxetine mesylate and a methacrylic acid-methyl methacrylate copolymer, where the weight ratio of paroxetine mesylate to polymer ranges from about 30:70 to about 90:10. Another solid dispersion contains amorphous paroxetine mesylate and a-vinylpyrrolidone/vinylacetate copolymer (PVP-VA), where the weight ratio of paroxetine mesylate to copolymer ranges from about 30:70 to about 50:50. An amorphous solid dispersion of the invention may have a single glass transition temperature. An amorphous solid dispersion is stable for at least 48 hours at 60° C. and 75% relative humidity. A further embodiment of the invention relates to pharmaceutical compositions of paroxetine mesylate comprising a solid dispersion of the invention and at least one pharmaceutically acceptable excipient. Methods for the treatment using paroxetine mesylate in the form of a solid dispersion according to the invention are also disclosed. |
申请公布号 |
US2016136148(A1) |
申请公布日期 |
2016.05.19 |
申请号 |
US201514937269 |
申请日期 |
2015.11.10 |
申请人 |
NOVEN THERAPEUTICS, LLC |
发明人 |
Engers David A.;Yang Yonglai;Parent Stephen;Houston Travis;Friedman Bruce Charles |
分类号 |
A61K31/4525;A61K47/32;A61K9/10 |
主分类号 |
A61K31/4525 |
代理机构 |
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代理人 |
|
主权项 |
1. A solid dispersion of amorphous paroxetine mesylate in a methacrylic acid-methyl methacrylate copolymer, wherein the weight ratio of paroxetine mesylate to polymer ranges from about 30:70 to about 90:10. |
地址 |
Miami FL US |