Compositions and Methods of Altering Cholesterol Levels

摘要

The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules. The present invention also relates to compositions and methods for altering cholesterol levels using polynucleotides, primary transcripts and mmRNA molecules.

主权项

1. A composition comprising;
(a) a first polynucleotide encoding a LDLR mutant having one or more amino acids substituted such that the LDLR mutant is deficient in PCSK9 binding, and (b) a second polynucleotide encoding a CYP7A1 protein, and (c) an excipient.