发明名称 |
REGULATED GENETIC SUICIDE MECHANISM COMPOSITIONS AND METHODS |
摘要 |
Embodiments of the present invention relates to the incorporation and use of a regulated genetic suicide mechanism for use in the improved purification of biologics, including adjunct use in various eubacterial minicell production and purification methodologies. Described herein are high-yield eubacterial minicell-producing strains with genetic modifications that comprise a regulated genetic suicide mechanism that irreparably destroys the parent cell chromosome such that live parental cells in a culture can be functionally eliminated at any time during the course of a minicell production and purification run. Embodiments of the present invention also describe methods useful in the elimination of live parental cells during the production of other cell-based biologics. |
申请公布号 |
EP3020811(A1) |
申请公布日期 |
2016.05.18 |
申请号 |
EP20150194851 |
申请日期 |
2009.06.23 |
申请人 |
VAXIION THERAPEUTICS, LLC |
发明人 |
GIACALONE, MATTHEW;TSUJI, SHINGO;MALOY, STANLEY |
分类号 |
C12N15/09;A61P31/04;C12N1/21 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|