ROTAVIRUS PARTICLES WITH CHIMERIC SURFACE PROTEINS
摘要
The present invention relates to the use of rotavirus particles for displaying a heterologous protein, alone or in complex with another molecule. The invention further relates to methods that employ these modified rotavirus particles to rapidly determine the structure of the heterologous protein or the complex using cryo-electron microscopy (cryo-EM). The invention also relates to a method of immunising a patient, wherein said method comprises administering to the patient the modified rotavirus particles of the invention.
申请公布号
EP3019518(A1)
申请公布日期
2016.05.18
申请号
EP20140736835
申请日期
2014.07.08
申请人
NOVARTIS AG;CHILDREN'S MEDICAL CENTER CORPORATION;BRANDEIS UNIVERSITY
发明人
DORMITZER, PHILIP R.;GRIGORIEFF, NIKOLAUS;HARRISON, STEPHEN;PAN, JUNHUA;SETTEMBRE, ETHAN