摘要 |
An object of the present invention is to provide a compound having a V2 receptor agonistic activity. Provided is a pharmaceutical composition which contains, as an active ingredient, a compound represented by the general formula (I) described below:
[wherein R 1 is the formula described below:
(wherein A is a lower alkylene group which may be substituted with a lower alkyl group, or the like; R 6 is a hydrogen atom, or the like; R 7 is a hydroxyl group, an aromatic heterocyclic group which may be substituted with a lower alkyl group, a carbamoyl group, or the like) ; R 2 is a hydrogen atom or a lower alkyl group; R 3 is a lower alkyl group which may be substituted with 1 to 3 fluorine atoms, or a halogen atom; R 4 is a five-membered aromatic monocyclic heterocyclic group, a five-membered non-aromatic monocyclic heterocyclic group, or the like, (provided that each of these heterocyclic groups contains at least one nitrogen atom and may be substituted with a lower alkyl group) ; and R 5 is a lower alkyl group, a halogen atom, or the like], or a pharmacologically acceptable salt thereof. |
申请人 |
SANWA KAGAKU KENKYUSHO CO., LTD |
发明人 |
KITAMOTO, KATSUNORI;KASUGAI, NOBUYOSHI;KATAOKA, HIROYO;OHSAWA, YASUSHI;KUNO, YUKA;FUJIEDA, HIROKI;SAKAI, KEITA;NAGANO, HIROKI;TAKAHASHI, NAOKI;IZUCHI, TORU;TAKEUCHI, MITSUAKI;KURUMAZUKA, DAISUKE;MIYAZAWA, TOSHIYUKI;HARADA, SATOKO;GOTOH, IZUMI;ASANO, YUKIYASU;YAMADA, YURIE;OKABE, MORIO |