| 摘要 |
The present invention relates to a transformed mammalian cell comprising a heterologous nucleic acid sequence (i) encoding a polypeptide comprising the catalytic domain of ST6Gal1 and, optionally, at least one nucleic acid sequence (ii) encoding a therapeutic protein comprising at least one glycosylation site, said transformed mammalian cell expressing the therapeutic protein with a sialylation on said at least one glycosylation site. |
