发明名称 |
弱塩基性選択性セロトニン5−HT3遮断剤および有機酸を含む薬物送達系 |
摘要 |
A pharmaceutical dosage form such as a capsule, a conventional or orally disintegrating tablet capable of delivering a weakly basic, nitrogen (N)-containing selective serotonin 5- HT 3 blocking agent having a pKa in the range of from about 5 to 14 and a solubility of not more than about 200 µg/mL at pH 6.8 into the body in a sustained-released fashion, suitable for a once-daily dosing regimen, comprises at least one organic acid, which solubilizes said weakly basic selective serotonin 5-HT 3 blocking agent prior to releasing it into the hostile intestinal environment wherein the blocking agent is practically insoluble. The unit dosage form may be composed of a multitude of multicoated particulates and is designed in such a way that the weakly basic blocking agent and the organic acid do not come into close contact during processing and/or storage thereby avoiding in-situ formation of acid addition compounds while ensuring that the acid is not depleted prior to completion of the drug release. |
申请公布号 |
JP5918179(B2) |
申请公布日期 |
2016.05.18 |
申请号 |
JP20130165542 |
申请日期 |
2013.08.08 |
申请人 |
アデア ファーマシューティカルズ,インコーポレイテッド |
发明人 |
ベンカテシュ,ゴピ,エム.;レイ,チン−ワン;ヴァヤス,ネハル,エイチ. |
分类号 |
A61K31/4178;A61K9/14;A61K9/20;A61K9/52;A61K47/10;A61K47/12;A61K47/14;A61K47/26;A61K47/32;A61K47/34;A61K47/38;A61K47/46;A61P1/08 |
主分类号 |
A61K31/4178 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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