发明名称 |
PURIFICATION METHOD FOR VIRUS-LIKE PARTICLES |
摘要 |
The present invention aims at establishing a novel means for purifying norovirus VLPs. There is provided a purification method of norovirus virus-like particles, comprising: contacting solution containing norovirus virus-like particles with support for hydroxyapatite chromatography, binding the virus-like particles to the support, subsequently washing the support with buffer, and then eluting the virus-like particles from the support with buffer containing phosphate, wherein the phosphate concentration of the buffer used for elution is less than 10 mM. |
申请公布号 |
EP3020721(A1) |
申请公布日期 |
2016.05.18 |
申请号 |
EP20140822108 |
申请日期 |
2014.05.21 |
申请人 |
UMN PHARMA INC.;VESIKARI, TIMO;BLAZEVIC, VESNA |
发明人 |
OKADA, MASAHIRO;MUKAI, AKIKO;NISHINO, TOMONORI;ARINOBU, DAISUKE;ITO, HIROYUKI;SATOH, MAMORU |
分类号 |
C07K1/16;C07K14/08;C12N7/02 |
主分类号 |
C07K1/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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