摘要 |
A method for the in vitro diagnosis of an invasive fungal infection by MALDI-TOF mass spectrometry. The method involves, providing a liquid biological sample from a mammal, said biological sample containing, in particular, proteins and/or lipids and/or salts and/or polysaccharides and/or oligosaccharides and/or monosaccharides capable of forming complexes with said proteins and/or lipids and/or salts; treating said sample with biological liquid so as to extract said polysaccharides and/or oligosaccharides and/or monosaccharides; determining, by MALDI-TOF mass spectrometry, whether or not there is present among said extracted polysaccharides, oligosaccharides and/or monosaccharides, at least one given compound of interest coming from said fungal microorganism and chosen from polysaccharides, oligosaccharides and monosaccharides; and deducing, if said given compound of interest is present in said sample, that said mammal is suffering from an invasive fungal infection. |
申请人 |
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE;UNIVERSITÉ DE DROIT ET SANTÉ DE LILLE;UNIVERSITÉ SCIENCES TECHNOLOGIES LILLE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
POULAIN, DANIEL;SENDID, BOUALEM;GUERARDEL, YANN;FRANCOIS, NADINE |