| 摘要 |
A polymer of fluorinated monomers and hydrocarbon monomers is provided. It is also provided a polymer blend that contains a polymer-formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer. The polymer or polymer blend described herein and optionally a bioactive agent can form an implantable device such as a stent or a coating on an implantable device such as a drug-delivery stent, which can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof. |
| 主权项 |
1. A biocompatible polymer comprising fluorinated monomers and hydrocarbon monomers, having the structure of formula I: wherein m and n are positive integers ranging from 1 to 100,000, wherein the fluoro monomers are fluorinated alkylene monomers, wherein the hydrocarbon monomers are hydrocarbon vinyl monomers, wherein the hydrocarbon monomers are CR2═CH2 in which R is methyl, ethyl, n- propyl, isopropyl, short chain alkyl group, phenyl, substituted phenyl, cyclic alkyl, heterocyclic alkyl, or heteroaryl, or CHR′═CH2 in which R′ is phenyl, substituted phenyl, cyclic alkyl, heterocyclic alkyl, or heteroaryl, wherein the fluoro monomers are selected from the group consisting of —CF2—CF2—, —CH2—CHF—, —CHF—CHF—, —CClF—CF2—, —CHF—C(CF3)F—, —CF2—C(CF3)H—, —CF2—CR″F—, —CHF—CR″F—, —CF2—CR″H—, —CH2—CR″F—, and —CFH—CR″H—wherein R″ is selected from Cl, Br, I, methyl, ethyl, n-propyl, iosopropyl, short chain alkyl groups, substituted phenyl, cyclic alkyl, heterocyclic alkyl, heteroaryl, fluorinated short chain alkyl groups, fluorinated phenyl, fluorinated cyclic alkyl, and fluorinated heterocyclic groups, wherein the fluorinated monomers form about 25.01 mole % to about 99.99 mole % repeating units of the polymer, and wherein the hydrocarbon monomers form about 74.99 mole % to about 0.01 mole % repeating units of the polymer. |
