发明名称 |
SUSTAINED RELEASE OF ANTIINFECTIVES |
摘要 |
Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 µm. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. |
申请公布号 |
CA2838108(C) |
申请公布日期 |
2016.05.17 |
申请号 |
CA20062838108 |
申请日期 |
2006.07.19 |
申请人 |
INSMED INCORPORATED |
发明人 |
BONI, LAWRENCE T.;MILLER, BRIAN S.;MALININ, VLADIMIR;LI, XINGONG |
分类号 |
A61K9/127;A61K9/00;A61K31/407;A61K31/545;A61K31/7036;A61K47/24;A61K47/28;A61P11/00;A61P31/04 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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