3-hydroxypropionic acid and other organic compounds

摘要

Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.

主权项

1. A transformed yeast or bacterial cell for producing 3-hydroxypropionic acid (3-HP), wherein the transformed cell comprises a metabolic pathway in which metabolites are sequentially produced in a sequence of pyruvate, acetyl-CoA, and malonyl-CoA, and wherein the transformed cell comprises
(i) a disruption of a gene encoding an alcohol dehydrogenase, (ii) a disruption of a gene encoding a pyruvate decarboxylase, or (iii) a disruption of both the alcohol dehydrogenase gene and the pyruvate decarboxylase gene.