发明名称 |
KOMBINATION AF TRANSMEMBRANAKTIVATOR OG CALCIUMMODULATOR OG CYCLOPHILIN-LIGAND-INTERAKTOR (TACI) OG ANTI-CD20-MIDLER TIL BEHANDLING AF AUTOIMMUN SYGDOM |
摘要 |
A therapeutically effective amount of an extracellular domain of a transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) polypeptide comprising a secreted form of SEQ ID NO:23 and an anti-CD-20 agent comprising rituximab, for use in reducing B cell numbers in a mammal, wherein said therapeutically effective amount results in a synergistic reduction in the number of memory B cells. |
申请公布号 |
DK2233149(T3) |
申请公布日期 |
2016.05.17 |
申请号 |
DK20100167232T |
申请日期 |
2008.10.16 |
申请人 |
ZYMOGENETICS, INC.;ARES TRADING S.A. |
发明人 |
BROLY, HERVE;PONCE JR., RAFAEL A.;GRAFFNER, HANS OTTO LENNART;PEANO, SERGIO |
分类号 |
A61K38/17;A61K39/395;A61P37/00;C07K16/28;C07K19/00 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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