发明名称 |
HLA binding motifs and peptides and their uses |
摘要 |
The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. One such peptide, NMLSTVLGV (SEQ ID NO: 183) is useful to elicit an immune response against influenza. The present invention also provides a heteropolymer of an isolated immunogenic peptide less than 15 amino acids in length comprising the oligopeptide NMLSTVLGV (SEQ ID NO: 183) and at least one different peptide. |
申请公布号 |
US9340577(B2) |
申请公布日期 |
2016.05.17 |
申请号 |
US200410817970 |
申请日期 |
2004.04.06 |
申请人 |
Epimmune Inc. |
发明人 |
Grey Howard M.;Sette Alessandro;Sidney John;Southwood Scott;Kubo Ralph T.;Celis Esteban;Chesnut Robert;Kast W. Martin |
分类号 |
A61K38/10;A61K39/145;C07K7/08;C07K7/06;A61K39/02;A61K39/12;C07K14/74;A61K38/00;A61K39/00 |
主分类号 |
A61K38/10 |
代理机构 |
Sterne, Kessler, Goldstein & Fox P.L.L.C. |
代理人 |
Sterne, Kessler, Goldstein & Fox P.L.L.C. |
主权项 |
1. A heteropolymer of an isolated immunogenic peptide less than 15 amino acids in length comprising the oligopeptide NMLSTVLGV (SEQ NO: 183) and at least one different peptide, wherein said at least one different peptide is not derived from influenza and is a cytotoxic T cell (CTL)-inducing peptide or a helper T cell (HTL)-inducing peptide. |
地址 |
San Diego CA US |