Substituted pyrazolo[3,4-a]carbazoles as hepatitis C inhibitors

摘要

The invention relates to compounds of Formula (I);
and pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are defined herein, and their use for the treatment of hepatitis C viral infection.

主权项

1. A compound, or a pharmaceutically acceptable salt thereof, having a formula wherein: R1 and R2 are each independently (C1-6)alkyl optionally monosubstituted or disubstituted with —O—(C1-6)alkyl, NH2, NH(C1-6)alkyl or N((C1-6)alkyl)2; R3 is H or (C1-6)alkyl optionally monosubstituted or disubstituted with —O—(C1-6)alkyl, NH2, NH(C1-6)alkyl, N((C1-6)alkyl)2, —C(═O)—(C1-6)alkyl, —SO2NH2, —SO2—NH(C1-6)alkyl, —SO2—N((C1-6)alkyl)2, —SO2(C1-6)alkyl, —C(═O)—NH2, —C(═O)—NH(C1-6)alkyl or —C(═O)—N((C1-6)alkyl)2; R4 is H, (C1-6)alkyl, (C3-7)cycloalkyl, —(C1-6)alkyl-aryl, —(C1-6)alkyl-heterocyclyl, —(C1-6)alkyl-heteroaryl, aryl, heterocyclyl or heteroaryl, wherein each alkyl, cycloalkyl, aryl, heterocyclyl and heteroaryl, either alone or in combination with another radical, is optionally substituted with 1, 2 or 3 R41; or R3 and R4, together with the nitrogen atom to which they are attached, are linked to form a heterocyclyl or heteroaryl, wherein heterocyclyl and heteroaryl are each optionally substituted with 1, 2 or 3 R41; R41 is each independently selected from the group consisting of halo, oxo, cyano, nitro, R42, —C(═O)—R42, —C(═O)OR42, —OR42, —SR42, —SOR42, —SO2R42, —N(R43)R42, —C(═O)—N(R43)R42, —N(R43)—C(═O)R42, —O—C(═O)—N(R43)R42 and —SO2—N(R43)R42; R42 is each independently selected from the group consisting of H, (C1-6)alkyl, (C3-7)cycloalkyl, —(C1-6)alkyl-aryl, —(C1-6)alkyl-heterocyclyl, —(C1-6)alkyl-heteroaryl, aryl, heterocyclyl and heteroaryl, wherein each alkyl, cycloalkyl, aryl, heterocyclyl and heteroaryl, either alone or in combination with another radical, is optionally substituted with 1, 2 or 3 substituents each independently selected from the group consisting of:
halo, cyano, OH, —COOH, —O—(C1-6)alkyl, (C3-7)cycloalkyl, (C1-6)haloalkyl, —C(═O)—(C1-6)alkyl, —SO2NH2, —SO2—NH(C1-6)alkyl, —SO2—N((C1-6)alkyl)2, —SO2(C1-6)alkyl, —C(═O)—NH2, —C(═O)—NH(C1-6)alkyl, —C(═O)—N((C1-6)alkyl)2, —NH2, —NH(C1-6)alkyl, —N((C1-6)alkyl)2, —NH—C(═O)(C1-6)alkyl and (C1-6)alkyl optionally monosubstituted or disubstituted with OH or —O—(C1-6)alkyl; and R43 is H or (C1-6)alkyl.