Methods and systems for determining the concentration of a contrast agent

摘要

A method for determining a concentration of a contrast agent in imaging data includes calculating a pre-contrast attenuation map of a region of interest of a patient. Following an administering of a contrast agent to the patient, a post-contrast attenuation map of the region of interest of the patient is calculated. An increase in attenuation value is determined based on the pre-contrast attenuation map and the post-contrast attenuation map and a contrast agent concentration map is calculated for the region of interest based on the increase in attenuation value.

主权项

1. A method for determining a concentration of a contrast agent in imaging data, the method comprising:
calculating a pre-contrast attenuation map of a region of interest of a patient; following an administering of the contrast agent to the patient, calculating a post-contrast attenuation map of the region of interest of the patient; determining whether a PET radiotracer tracer has reached a steady-state biological distribution in the patient, comprising:
acquiring first PET tracer kinetics prior to the administering of the contrast agent to the patient;acquiring second PET tracer kinetics after the administering of the contrast agent to the patient; anddetermining whether the PET radiotracer tracer has reached the steady-state biological distribution by comparing the first PET tracer kinetics with the second PET tracer kinetics; and if the PET radiotracer tracer has not reached a steady-state biological distribution, adjusting the post-contrast attenuation map to reflect a change in biological distribution between the pre-contrast attenuation map and the post-contrast attenuation map; determining an increase in attenuation value based on the pre-contrast attenuation map and the post-contrast attenuation map; and calculating a contrast agent concentration map for the region of interest based on the increase in attenuation value.