主权项 |
1. A compound of formula (I) wherein R1 is selected from a group consisting of:
halogen, CN, OH, C1-6-alkyl, C3-7-cycloalkyl, —(C1-3-alkyl)-(C3-7-cycloalkyl), —O—(C1-6-alkyl), —O—(C3-7-cycloalkyl), —O—(C1-3-alkyl)-(C3-7-cycloalkyl), —O-phenyl, —O—(C1-3-alkyl)-phenyl, —COOH, —COO(C1-4-alkyl), —CO—NH—(C1-3-alkyl)-phenyl, —CO—NH—(C1-6-alkyl), —NH—(C1-6-alkyl), —NH—(C3-7-cycloalkyl), —NH—[(C1-3-alkyl)-(C3-7-cycloalkyl)] and NH—(C1-3-alkyl)-phenyl,wherein each alkyl and cycloalkyl is optionally substituted with one or more substituents selected from F and CF3; andwherein the hydrogen atom in each NH group is optionally replaced with C1-6-alkyl;or, if two R1-groups are attached to adjacent carbon atoms of the phenyl moiety of the tetrahydroisoquinolinyl group, they may be linked with each other and together form a C3-5-alkylene bridging group in which 1 or 2 —CH2-groups may independently of each other be replaced by —O—, —C(═O)—, —S—, —S(═O)—, —S(═O)2—, —NH— or —N(C1-4-alkyl)-;
n is 0, 1, 2 or 3; R2 is selected from a group consisting of: H, C1-6-alkyl, C3-7-cycloalkyl, NH2, —NH—(C1-6-alkyl), —N(C1-6-alkyl)2, —O—(C1-6-alkyl), heterocyclyl, 5-membered heteroaryl containing 1 or 2 heteroatoms selected from O, S, N and NH, 6-membered heteroaryl containing one or two nitrogen atoms, and —(C1-3-alkyl)-(6-membered heteroaryl containing one or two nitrogen atoms);
wherein each alkyl group is optionally substituted with one or more substituents selected from F, CN, CONH2, CONH(C1-3-alkyl), CON(C1-3-alkyl)2, NH2 and OH,wherein each cycloalkyl group is optionally substituted with one or more substituents selected from F, CN, OH, NH2, NH(CO)OC1-6-alkyl, C1-3-alkyl and CF3,wherein each heteroaryl group is optionally substituted with one or more substituents selected from F, Cl, C1-3-alkyl, NH2 and —NH—C(O)—(C1-3-alkyl), andwherein the heterocyclyl group is selected from a group consisting of 2-oxo-pyrrolidinyl, 2-oxo-dihydrofuranyl and morpholinyl; R3 is H or C1-4-alkyl; R4 is H or C1-4-alkyl; R5 is H or C1-3-alkyl; R6 is F, OH or —O—(C1-4-alkyl), or, if m is 2, both R6 groups together with the carbon atom, to which they are attached, may form a carbonyl group; and R7 is H, C1-4-alkyl, —COOH or —COO(C1-4-alkyl), and m is 0, 1 or 2;wherein each of the above-mentioned alkyl and —O-alkyl groups may be substituted by one or more F;or a pharmaceutically acceptable salt thereof. |