System, method and article for normalization and enhancement of tissue images

摘要

In medical imaging, a fiducial marker facilitates tissue image correlation that allows for image analysis, normalization and correction of the optical exposure and spectral and spatial distribution in order to compensate for the surface reflections, sub surface tissue interactions and spatial orientation of the excitation and imaging axes to the subject tissue. Using a cross comparison, clinicians can model tissue image data in different forms in order to reference and compare data from various spectral components and or from different images. This may enhance human interpretation between images including the variations between images even when the spectral, spatial and optical conditions or the image resolution or sensitivity are compromised. Such may be used to assess cosmetic, moisturizing, therapeutic materials and treatments.

主权项

1. A system for use in tissue analysis, the system comprising:
at least one processor; and at least one nontransitory storage medium that stores processor executable instructions which when executed cause the at least one processor to: compare an appearance of at least one shape of a virtual fiducial marker in a first digital image of a portion of a tissue to at least one defined actual shape of the virtual fiducial marker; compare an appearance of each of a plurality of sections of a physical fiducial marker in the first digital image to respective ones of defined sections of the physical fiducial marker, wherein the defined sections include a number of tissue phantoms each having a respective spectral characteristic that matches a respective spectral characteristic of tissue of a type represented in the first digital image; and at least one of correlate, normalize, or correct at least the first digital image, based at least in part on the comparisons; the system being characterized in that the physical fiducial marker includes a scatter layer that overlies at least some but not all of the tissue phantoms and which simulates an optical character of the type of tissue represented in the first digital image, and the instructions cause the at least one processor to compare the appearance of the sections which include the tissue phantoms which are overlaid by the scatter layer with a number of defined sections which include tissue phantoms that are not overlaid by the scatter layer.