Thermo-sensitive, mucoadhesive or dermoadhesive, and penetration-enhancing formulations for topical delivery of therapeutics

摘要

The present invention provides thermo-sensitive, mucoadhesive biopolymer formulations that enhance the penetration of therapeutics across the skin or mucosal surfaces. In a preferred embodiment, the biopolymer formulation comprises co-polymer of poloxamer 188 and propylene glycol, laurocapram and, optionally, one or more therapeutic agents. Also provided are uses of the biopolymer formulations for topical therapy of cancer including cervical cancer.

主权项

1. A composition for topical delivery of therapeutics across the skin or mucosal surfaces comprising poloxamer 188, propylene glycol, laurocapram and a vaccine antigen selected from the group consisting of: tumor antigens, viral antigens, bacterial antigens, fungal antigens, parasite antigens and allergens.