Compositions and methods for the treatment of restless leg syndrome and fibromyalgia

摘要

The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of fibromyalgia, restless leg syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of motor neurone disease, diabetic neuropathy, postherpetic neuralgia, acute opioid withdrawal management, obsessive-compulsive disorder, premature ejaculation, PTSD, injury, post-operative pain, osteoarthritis, rheumatoid arthritis, multiple sclerosis, spinal cord injury, migraine, HIV related neuropathic pain, bipolar depression, depression, stress, cancer pain and lower back pain.

主权项

1. A compound of Formula I: or a pharmaceutically acceptable salt, enantiomer, or stereoisomer thereof, wherein: R1 and R2 each independently represent R3 and R4 each independently represent D, CH3, CD3, —OCH3, a is 2, 3 or 7; each b is independently 3, 5 or 6; e is 1, 2 or 6; c and d are each independently H, D, —OH, -OD, C1-C6-alkyl, —NH2 or —COCH3; n is 0, 1, 2, 3, 4or5; R5 represents —F, -D, each a is independently 2, 3 or 7; each b is independently 3, 5 or 6; each e is independently 1, 2 or 6; each c and each d are each independently H, D, —OH, -OD, C1-C6-alkyl, —NH2 or —COCH3; and each n is independently 1, 2, 3, 4 or 5.