| 发明名称 | Method for enhancing red blood cell quality and survival during storage | ||
| 摘要 | The present invention is a method for enhancing the quality and survival of red blood cells during storage by depleting the red blood cells of both carbon dioxide and oxygen and maintaining 2,3-diphosphoglycerate acid levels. | ||
| 申请公布号 | US9339025(B2) | 申请公布日期 | 2016.05.17 |
| 申请号 | US201113218114 | 申请日期 | 2011.08.25 |
| 申请人 | New Health Sciences, Inc.;Trustees of Dartmouth College | 发明人 | Yoshida Tatsuro;Dumont Larry J. |
| 分类号 | A01N1/02;A61M1/02 | 主分类号 | A01N1/02 |
| 代理机构 | Arnold & Porter LLP | 代理人 | Arnold & Porter LLP |
| 主权项 | 1. A method for enhancing red blood cell quality and survival during storage comprising (a) depleting a red blood cell sample of leukocytes; (b) depleting said leukocyte depleted red blood sample of platelets; (c) adding an additive solution having a pH ranging from 5.5 to 7.0; (d) depleting said leukoreduced and platelet reduced red blood cell sample of both oxygen and carbon dioxide prior to storage, wherein carbon dioxide is depleted to a level of 5 mmHg at 21-25° C.; and (e) transferring the leukocyte, platelet and oxygen- and carbon dioxide-depleted red blood cell sample to an oxygen- and carbon dioxide-impermeable environment for storage, wherein said red blood cell sample has an acidic pH, thereby enhancing red blood cell quality and survival during storage. | ||
| 地址 | Bethesda MD US | ||