Methods of treating amyotrophic lateral sclerosis

摘要

The present invention relates to use of DHA analogs and their pharmaceutical compositions for treating ALS, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

主权项

1. A method for reducing oxidative stress associated with amyotrophic lateral sclerosis (ALS) comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula I: or a pharmaceutically acceptable salt, ester, solvate, hydrate or prodrug thereof, wherein reducing oxidative stress associated with ALS comprises one or more of (a) reducing cell death; (b) reducing neurodegeneration; or (c) increasing cell survival of a cell from the subject suffering from ALS, wherein said cell is a motor neuron and said method increases motor neuron survival by at least 39%.