发明名称 |
PHARMACEUTICAL COMPOSITIONS COMPRISING MACROLIDE DIASTEREOMERS, METHODS OF THEIR SYNTHESIS AND THERAPEUTIC USES |
摘要 |
The disclosure relates to compositions comprising diastereomer of a macrolide exhibiting improved therapeutic profile in the context of inhibiting cell proliferation compared to the corresponding compositions comprising mixture of diastereomers. The disclosure further provides drug-ligand conjugates formed using diastereomer of the macrolide. The disclosure also provides novel method of preparation of diastereomer of the macrolide and their therapeutic uses. |
申请公布号 |
PH12016500380(A1) |
申请公布日期 |
2016.05.16 |
申请号 |
PH12016500380 |
申请日期 |
2016.02.26 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
NITTOLI, THOMAS;JAIN, NARESHKUMAR F.;MARKOTAN, THOMAS PATRICK |
分类号 |
A61K31/5365;A61P29/00;A61P35/00;A61P37/00;C07D413/14 |
主分类号 |
A61K31/5365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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