| 摘要 |
PROBLEM TO BE SOLVED: To provide an orally disintegrating olanzapine tablet in which the increase of analogues by oxidative degradation or a degradation mechanism thereof is reduced over the long time.SOLUTION: The invention provides an orally disintegrating olanzapine tablet preserved in a packaging form where a drying agent having a deoxidation function which utilizes the oxidation mechanism of organic substances is enclosed. Preferably, the drying agent has a deoxidation function and is enclosed in an organic deoxidant, and preferably, the drying agent is also used in combination with the drying agent having a deoxidation function. Preferably, the orally disintegrating tablet has a packaging form of a pillow package or a bottle package. The orally disintegrating olanzapine tablet in which excellent stability is imparted reduces the temporal increase of many degradation products (analogue B, analogue C, thiolactam body, lactam body, and the like) derived from olanzapine, by the packaging form.SELECTED DRAWING: None |
