发明名称 |
METHOTREXATE ADJUVANTS TO REDUCE TOXICITY AND METHODS FOR USING THE SAME |
摘要 |
Methods are provided for using methotrexate (MTX) active agents in which reduced host toxicity is observed. Aspects of the methods include administering to a subject an effective amount of an MTX active agent in conjunction with a MTX toxicity-reducing adjuvant, such as a 2,2′-anhydropyrimidine, a derivative thereof or a uridine phosphorylase inhibitor. Also provided are compositions and kits that find use in practicing embodiments of the invention. The methods and compositions find use in a variety of applications, including the treatment of a variety of different disease conditions. |
申请公布号 |
HK1210948(A1) |
申请公布日期 |
2016.05.13 |
申请号 |
HK20150111745 |
申请日期 |
2015.11.30 |
申请人 |
TOSK INCORPORATED |
发明人 |
GARLAND, WILLIAM;FRENZEL, BRIAN;KARG, TRAVIS;WIPKE, TODD;KONOPELSKI, JOSEPH |
分类号 |
A61K;A61P |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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