PREPARATION, USES AND SOLID FORMS OF OBETICHOLIC ACID

摘要

PROBLEM TO BE SOLVED: To provide a preparation, uses, and solid forms of obeticholic acid which is useful for the treatment or prevention of FXR mediated diseases and conditions, cardiovascular disease, or cholestatic liver disease; and is useful for decreasing HDL cholesterol, decreasing triglyceride in mammals, or inhibiting fibrosis.SOLUTION: The invention provides a pharmaceutical composition containing a crystalline obeticholic acid form C of the obeticholic acid represented by the following formula and an obeticholic acid form 1.SELECTED DRAWING: Figure 5