SELECTIVE CANCER TRACKING ERADICATOR AND THE USES THEREOF

摘要

The present invention discloses a new modality of photodynamic therapy (PDT) through the design of the present invention's truly dual-functional—PDT and imaging—gadolinium complex (Gd-N) with a molecular formula of:;;which can target cancer, cells specifically. The present invention provides a PDT drug that can specifically localize on the anionic cell membrane of cancer cells in which its laser-excited photoemission signal can be monitored without triggering the phototoxic generation of reactive oxygen species—singlet oxygen—prior to due excitation. The present invention also provides the use of Gd-N as a tumor selective PDT photosensitizer modality.

主权项

1. A composition for photodynamic therapy and imaging of cancer cells comprising gadolinium complex with a molecular formula of:wherein Ln is Gd or gadolinium porphyrinate (Gd-N) or a pharmaceutically acceptable salt thereof.