SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

摘要

The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.;

主权项

1. A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein:
X is Bis a) Ar; or
b) —C(═O)NHCR5R6Ar; orX together with B is Ar is an aromatic ring system selected from:
5-6 membered monocyclic ring with 0, 1, or 2 N ring atoms, optionally substituted with halo or fluorophenyl; and(ii) 9-10 membered bicyclic rings with 0, 1, 2 or 3 heteroatom ring atoms selected from N and O, which is optionally substituted with 1 or 2 substituents independently selected from C1-C6 alkyl, F, cyano, and alkylalkoxy;A is fluorophenyl;D is absent or NR3SO2R4;Ra is C1-C6 alkyl or C1-C6 haloalkyl;R2 is C1-C6 alkyl;R3 is C1-C6 alkyl;R4 is C1-C6 alkyl;R5 is hydrogen, C1-C6 alkyl, or C1-C6 hydroxyalkyl;R6 is hydrogen; orR5 and R6 together with the carbon to which they are attached form cyclopropyl.