INHALATION COMPOSITION FILLING METHOD

摘要

The present invention relates to pharmaceutical powder compositions used by means of inhalation devices. The present invention more particularly relates to a filling method which provides an ideal volume and density for the compositions used in inhalation devices and delivers a desired amount of a fine particle dose to the patient.

主权项

1. A filling method of an inhaler composition, characterized in that a composition
having a bulk density ranging from 0.48 to 0.56 g/L, a compressed density ranging from 0.78 to 0.92 g/L, and a d(50) particle size ranging from 30 to 50 μm, and comprising 0.2 to 1.7% by weight of salmeterol with a d(50) particle size distribution ranging from 1 to 3 μm and 0.2 to 17.0% by weight of fluticasone with a particle size distribution ranging from 1 to 3 μm, 1 to 20% by weight of fine particle lactose with a d(50) particle size ranging from 2 to 10 μm, and 80 to 99% by weight of coarse particle lactose with a d(50) particle size ranging from 50 to 120 μm, is taken into a reservoir by applying a vacuum of 900 mBar to 0.01 mBar and then stopping the applied vacuum and transferring the composition into the blister cavity.