Method of a Pharmaceutical Delivery System for Use Within a Joint Replacement

摘要

Methods and apparatus of providing a joint replacement parts with a pharmaceutical delivery system is provided. The pharmaceutical delivery system is placed within the joint replacement parts to provide, over a period of time, sustained release of a controlled concentration of pharmaceuticals within the joint space of the joint replacement and to produce a local or systemic physiological of pharmacological effect.

主权项

1. A method to delivery drug for the sustained administration of a pharmaceutical into a joint replacement at a controlled rate to produce a beneficial response, said method comprising:
a. providing a body comprising at least one portion of pharmaceutical mixed with at least one portion of polymer; b. preparing a joint replacement having an insert wherein said insert contains an opening; c. placing said body inside said opening without interfering with said joint replacement's normal operation; d. sealing said body within said opening with a membrane; e. wherein said membrane is comprised of a material which allows for said pharmaceutical to diffuse across said membrane; f. wherein said material further determines the diffusion rate of said pharmaceutical crossing said membrane.