| 发明名称 |
COMPOSITIONS AND METHODS FOR TREATING CANCER |
| 摘要 |
The instant invention relates to methods for the treatment of B-cell lymphomas and leukemia by administering a SYK inhibitor. In another embodiment, the invention relates to a method for treating a patient diagnosed with a B-cell lymphoma or leukemia, comprising administering a SYK inhibitor, wherein the B-cells of said patient to be treated are characterized by elevated expression levels of CD86. |
| 申请公布号 |
US2016130659(A1) |
申请公布日期 |
2016.05.12 |
| 申请号 |
US201414894705 |
申请日期 |
2014.06.03 |
| 申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
MacIsaac Kenzie;Kraus Manfred;Strack Peter Richard;Nagashima Kumiko;Ellis John Michael |
| 分类号 |
C12Q1/68;C07K16/28;G01N33/574 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating a patient diagnosed with a B-cell lymphoma or leukemia with a SYK inhibitor comprising the steps of:
(a) selecting a patient for treatment with a SYK inhibitor, wherein a malignant B-cell containing biological sample of the patient has elevated CD86 expression; and (b) administering a therapeutically effective amount of the SYK inhibitor to the selected patient. |
| 地址 |
Rahway NJ US |
