DIAGNOSTIC, PROGNOSTIC, AND MONITORING METHODS FOR MULTIPLE MYELOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, AND B-CELL NON-HODGKIN LYMPHOMA

摘要

The invention generally provides improved compositions and methods for detecting, diagnosing, prognosing, and monitoring multiple myeloma, chronic lymphocytic leukemia, or B-cell non-Hodgkin lymphoma in a subject. In particular, the invention provides methods for detecting BCMA in subjects to reliably diagnose, predict survival, or monitor multiple myeloma, chronic lymphocytic leukemia, or B-cell non-Hodgkin lymphoma in the subject.

主权项

1. A method of diagnosing multiple myeloma (MM), comprising:
(a) detecting an amount of BCMA polypeptide or a fragment thereof in a biological sample obtained from a subject; and (b) comparing the amount of BCMA polypeptide or fragment thereof detected in step (a) to a predetermined cut-off value or to an amount detected in a control serum sample, wherein an increased amount of BCMA polypeptide or fragment in the biological sample of (a) as compared to the predetermined cut-off value or amount in the control serum sample of (b) indicates the presence of MM, wherein the biological sample is a serum sample or supernatant obtained from culture of the subject's bone marrow mononuclear cells or peripheral blood mononuclear cells.