| 发明名称 |
Interleukin 15 (IL-15) Antagonists and Uses Thereof for the Treatment of Autoimmune Diseases and Inflammatory Diseases |
| 摘要 |
The present relates to interleukin 15 (IL-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory diseases. In particular, the present invention relates to an IL-15 mutant polypeptide having the amino acid sequence as set forth in SEQ ID NO:1 wherein the leucine residue at position 45 is substituted by an aspartic acid residue, the asparagines residue at position 65 is substituted by a lysine residue and the leucine residue at position 69 is substituted by an arginine residue |
| 申请公布号 |
US2016130318(A1) |
申请公布日期 |
2016.05.12 |
| 申请号 |
US201414897344 |
申请日期 |
2014.06.27 |
| 申请人 |
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ;UNIVERSITÉ DE NANTES ;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ;UNIVERSITE D'ANGERS |
发明人 |
Jacques Yannick;Mortier Erwan;Quemener Agnes;Plet Ariane |
| 分类号 |
C07K14/54 |
主分类号 |
C07K14/54 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An IL-15 mutant polypeptide having the amino acid sequence as set forth in SEQ ID NO:1 wherein the leucine residue at position 45 is substituted by an aspartic acid residue, the asparagine residue at position 65 is substituted by a lysine residue and the leucine residue at position 69 is substituted by an arginine residue. |
| 地址 |
Paris FR |
