发明名称 |
METHOD FOR PREDICTING RESPONSE TO CANCER TREATMENT |
摘要 |
It has been found that BRG1 and BRM have a synthetic-lethal relationship, and that a treatment for inhibiting BRM is a promising approach for treating a BRG1-deficient cancer having no mutation in known therapeutic target genes. Moreover, it has also been revealed that, in this therapeutic strategy, a BRM inhibitor may be administered to a cancer patient after the selection based on BRG1 function suppression, thus enabling an efficient treatment based on the companion diagnosis. |
申请公布号 |
US2016130663(A1) |
申请公布日期 |
2016.05.12 |
申请号 |
US201414904188 |
申请日期 |
2014.07.11 |
申请人 |
NATIONAL CANCER CENTER ;DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
Kohno Takashi;Tsuta Koji;Tominaga Yuichi;Ito Kentaro |
分类号 |
C12Q1/68;G01N33/50;C12N15/113;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
1. A method for evaluating a cancer, the method comprising detecting whether or not a BRG1 function is suppressed in a biological sample derived from a cancer patient. |
地址 |
Tokyo JP |