METHODS OF TREATING CKD USING PREDICTORS OF FLUID RETENTION

摘要

The disclosure relates to methods of treating chronic kidney disease and diabetic nephropathy using predictors of fluid retention to minimize the risk of adverse events. The methods disclosed are particularly useful in treatments involving endothelin receptor antagonists, and more particularly, atrasentan and pharmaceutically acceptable salts thereof.

主权项

1. A method of treating chronic kidney disease with an endothelin receptor antagonist (ETRA) comprising:
measuring one or more of eGFR, blood pressure, HbA1c, or HOMA-product in a subject suffering from chronic kidney disease; determining, based on the measurement, risk of fluid retention if an ETRA were administered to the subject; and administering the ETRA to the subject if the risk is at an acceptable level.