发明名称 |
COMBINATION THERAPY COMPRISING OX40 BINDING AGONISTS AND TIGIT INHIBITORS |
摘要 |
The present disclosure describes combination therapy comprising an OX40 binding agonist and an agent that decreases or inhibits TIGIT expression and/or TIGIT activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired, such as increasing tumor immunogenicity for the treatment of cancer or chronic infection. |
申请公布号 |
WO2016073282(A1) |
申请公布日期 |
2016.05.12 |
申请号 |
WO2015US58087 |
申请日期 |
2015.10.29 |
申请人 |
GENENTECH, INC.;F. HOFFMANN-LA ROCHE AG |
发明人 |
KIM, JEONG, M.;GROGAN, JANE, L. |
分类号 |
C07K16/28;A61K39/395;A61P35/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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